The Focus Fuel pump will be iffy and the 42's should take you to right around 80-85% BSFR, which is about as high as you'll want to run them. Bigger might be better in this case, but I'm pretty confident that the 42's will hold out.
The Transmission should hold up well as long as you're not constantly pushing the envelope. Your car actually utilizes a 4R70W, not an AOD(E) and since you’re running a New Edge car the valve body and many internal parts have been improved over the earlier model years before it. Basically, it's as good a unit as you’ll get from the factory. You'll also be able to tighten up your shifts and play with your shift points with an XCal 2 (assuming that's what you'll be using to tune the car for the blower) and a transmission cooler will be an
absolute must for transmission longevity.
All that being said, if you're pulling the engine and trans as it is, you'd be a fool not to install a decent triple disk, high stall torque converter while you're at it (something built by a reputable company like PI, Circle D, etc). Go for something that stalls in the 3,600-3,800 range (you'll be wasting your time otherwise). That'll knock an easy 3-5 tenth’s off of your times alone and make your car feel much livelier on the street. Don't be afraid of a little stall speed, you'll be used to it after about 15-minutes worth of driving and won't know how you drove your car without it afterwards! While you’re on it, if you haven’t already done so, swap out your rear end gears to something in the 3.73-4.10 range to compliment the converter and you’ll feel like you’re driving a whole different car!
The above driveline formula, combined with your projected 500rwhp levels is a recipe for an easy low 11-second ride that’ll still maintain great street manners.
