As far as putting cams in a super charged car. Yes you can do it and it will run but, with bigger cams you have to run less boost to prevent power loss, detonation, and a problem with unmeasured air and floating the valves to much. If you want to make great power with out cams, heads, notched pistons, and such. Go with the KB 2.1L. I had one and on the 14psi pulley i made 407RWHP and 512ftlbs of torque at a little over 6000 ft elevation.
Lowering the boost to run with big cams to prevent power loss? I don't know where you get that from.
Running big cams will lower the boost for a given pulley size, because there is less back pressure and a higher flow rate. But it has nothing to do with preventing power loss. You just go to a smaller pulley (which turns the supercharger faster) to reach the same boost level. So know you have the same boost, but allot more flow... which translates into higher horsepower.
Detonation issues due to the boost and cams? Detonation can be caused by a poor air fuel ratio (which is controlled by the fuel injector size and the tune), high IAT's, high compression, bogging the engine down, too much boost, and poor gas, and not much to do with the cams.
Floating the valves has to do with cam profile, spring stiffness, and rpm, not boost (at least at boost levels appropriate for a street car. If you are running 30 to 50 lb boost, that might be a different story... but that ain't going to be a street car.
A problem with unmeasured air? Only if your MAF is screwed up, or you don't have a MAF capable of the higher flow rates, or don't have the proper MAF transform in the tune, or you have a vaccuum leak.
The big issue with high lift cams and blowers is that big cams don't pull much vaccuum, so you will have issues with it the bypass valve wanting to go into boost unless you get a low vaccuum bypass valve. Even then they want to go into boost at low throttle settings / rpms.
Truthfully, if I had to do it over again, I would install much less aggressive cams. I have Comp Stage 1 blower cams with a KB 2.6, and the low vaccuum bypass valve diaphram. Even with the low vaccuum diaphram, it still goes into boost at low throttle settings, which is turning out to be a total pain in the but. And then there is the VCT issues the big cams / stiff springs have caused.
Unless you are going to trailer it to the drag strip, don't mess with the cams on a roots or twin screw setup.
Most 3 valve KB's are 2.6L and usually put out close to 500 hp at 10 to 11 psi on a stock engine. They also make a 2.8 kit as well, and the smallest I remember them making for the 3V was a 2.4L.