12's and 10's are a big difference. Shoot, a 11.0 to a 10.5 is a huge difference. A good drag radial is where I would start for 10's. Then, you will need a solid clutch and a lot of power for a stick car.
It seems that every car has a different sticking point for ET's(or threshold) given their setup when the ET just doesn't come down much regardless of what you do.
If you do full race
suspension, slicks/skinnies, then it changes things. I've never liked to touch the
suspension on my cars(my 3 2v mustangs, except lowering them), and prefer to run them the way I do on the street everyday. It is really up to you what you want to do with the car.
Either build the crap out it with a lot of HP, a strong clutch, sub-frame connectors, and a good drag radial, or make it a drag purpose car with
suspension, removing weight, built rear, gears, etc. You need to decide on if it is a street car or a car that is driven on the street but only intended for 1/4 racing.