The best way to think of it maybe isn't the target horsepower, but the goal of the car. Say you wanted to run 10.50 in the 1/4, with gobs of power down low, pretty much instantly off idle, with full accessories including A/C. You could toss a 351 with something like an Eagle forged rotating assembly, decent blower/turbo cam and some AFR 185 or 205cc heads, with probably a small single turbo. Or if your goal was to have decent manners off idle, but make power as the RPM increases, a centrifugal supercharger setup might be for you. You could get there several ways, so knowing your ultimate goal is important for us to give proper advice. Know what I'm sayin'?