WHAT!?! I get 20MPG highway in my car with my current combo, heavy ass car, my heavy rotating assembly in the TKO (its 16lbs more rotating mass than a T5!), 315 series tires, AND 4.10's!!! I originally had 3.73's in my car and ultimately switched to 4.10's. The ONLY and I mean ONLY time I would not opt for the 4.10's is in a DD out in the great planes states (ie flat as a board) or in a car with definite forced induction in its future. In ANY other case, I'd concider 4.10's a minimum. I take it by your location you are up in the northeast where we have mountains and such not pure flat roads... go 4.10's. They do NOT make you bite the steering wheel when you leave off the gas, they do not zap like 10mpg out of your car, and the revs are not that bad at all on the highway.
Don't fear the gear!