It would be best if you posted the Holley list number of the carb. What I am saying here is based on my 80457 carbs. These are 600 cfm universals with a Ford kickdown linkage for a C4 or C6.
The vacuum secondary opens when vacuum is applied to the vac cannister. The vacuum is venturi vacuum from the primary bores, not manifold vacuum. The passage comes out the side of the main body through a small hole that lines up with a boss and a passage in the vac secondary unit. Take the vac unit off and make sure the little cork gasket is there. New ones have sticky on them.
The last one I had trouble with ended up with the actual vacuum diaphram having a leak because I pinched it putting the cover on a couple years ago.....
When you have the vacuum unit off, test the diaphram with a vac pump or other means to see that it does not leak. If it leaks, take the cover off and see if the vacuum diaphram has leaks, or if it was not clamped between the base and cover.
Sorry for the long reply, but that's the best I can explain it.
Otherwise, make sure the diaphram, shaft and linkage move freely, etc.