I ran around 340RWHP and shot a 175 wet kit, worked great but the car made a ton of torque and was a handle full to drive the first 330ft or so...
The thing a lot of guys worry about is the stock rod bolts, you rarely hear of a stock rod breaking or even the crank unless omething else goes wrong. Anything can happen but if the tune is there I think you'll have no problems with a 125+, just make sure the rest of your system is up to par, fuel etc..and learn how to read and tune the car, start with the small shot and go from there.
FWIW, my car went 11.80 @ 116mph on motor (needed more gear) (91-92mph in the 1/8)
On a 175 shot I only 1/8'd like a 11.70 car @ 100mph since it was a wild ride but once I could get the tires to hook and car to go straight I would pick up 30mph on the last 1/8.
Car made 450RWHP and 740FTTQ on the bottle...torque monster! Stock rods, stock rod bolts, stock main bolts, stock pistons...I was taking way to many chances.
I can't wait to shoot 300+ through the new combo, which should have well over 500RWHP as well...