I've only known one person who successfully made a speed-density Mustang run 24lb injectors on the stock computer without a custom tune. I haven't talked to him in about 10 years though. That guy was a math wiz who figured out how to balance the amount of air going into the engine with the increase in fuel while keeping the vacuum within the range the ECU was designed for so that it wouldn't know the difference. Even then it would "hunt" at idle when cold until it warmed up, but once warmed up it could even pass California smog.
That guy was weird. He was also one hell of a good friend. I drove the car once, it was a beast.
Everyone else goes mass air for a reason, it's far easier.