To begin with, add 40% volume to your fuel system requirements to be conservative. So, if you needed 30 lbs injectors before, you'd need 42s now. On top of having roughly 38% less energy per unit volume, it also likes running a little richer for peak power on the lambda scale.
The biggest things you're missing is availability, the corrosive effect of methanol to non-stainless fuel system parts. It's not just about upping the injector capacity, and the pump to deliver it. Anything aluminum in your fuel system needs to be hard anodized, or replaced. That mild steel line that runs between the tank and the rails will probably have to be upgraded as well. The other volume related issue is mileage....and the same multiplier's effect in a negative way on that.
If you have to up your fuel delivery by 40%, a car that was getting 16 mpg cruising is now gonna get significantly less. Whether or not it'll drop all the way to 12....IDK. The same goes to range...if you could go 160 miles on 10 gals of premium gas, and that's all the E85 you get till the next station that is 160 miles away.........you now are gonna have to push the car the last 30-40 miles.