I replaced my C4 with a TKO 600 in my 69. I bought the kit from Modern Driveline. With their crossmember there is about a half inch of clearance between it and the tunel in my car. The angle at the front yoke is not great but its not bad either. I do not have any vibrations at all so Im not worried about the angles.
Their crossmember does drop the back end down a little bit though which in turn made my distributor rub on the monte carlo bar. I put a set of Ron Morris Lowered motor mounts and the engine is back to normal and it also helped out on the angle at the front yoke as well. The forward and aft adjustment will help out alot with getting the trans lined up on its cross member also.
If you are really concerned with the angles, you will have to modify the tunnel to get everything perfect.
If you are putting the Tremec 6 speed in you will have to modify the tunnel for sure.
I highly recommend Modern Driveline. The complete kit from them was a no BS, Completely bolt on kit. The only modifications I had to do was to drill a hole for their cable clutch setup.
They also know their products very well and were able to answer all of my questions right over the phone.