I personally run edelbrock carbs, the thunder series, but have also run a holley 750, I tuned each of them my self and think overall the holley is only a tad bit more work but still pretty simple to tune, my only reason for running the eddy's is that they are just more reliable, (less parts inside to go bad), I do believe for performance the holley carb would prolly make a tad more power but nothing drastic, if it's a street car go eddy or holley if its a race car.
The eddy carb I used was on a 420hp chevy 350 which I daily drove for about a year until I sold it,never had a problem, the holley was on a friends truck that I built an engine for, also a 350 but it was a pure track engine making close to 500hp or more, also no problems with the holley, so I say its up to you.
Daily=Edelbrock
Race=Holley