I'd strip the rear interior quarter panels down if they have been painted numerous times before. There's a cool grain pattern to the metal that gets lost with multiple layers of paint. The best way to do this is with some aircraft stripper and steel wool or similar. My doors were repros so I didn't have to deal with stripping them, but frankly I'd use the same method on there too. It's not that big of a deal really. I think the NPD paint is the one with a good fan-spray nozzle and is lacquer-based, so make sure your primer is lacquer-based too. (Any primer that says "fast drying" -- 15 minutes or less -- is usually lacquer.)
Pic of factory grain after stripping and painting