It seems like you are most likely to have a blown power valve if you had a misfire up your intake manifold. I had inserted my distributer off a little, had a misfire through the manifold, then the car started to run really badly(worse than just the timing problem). After just a few miles of running REALLY richly, I had so much carbon in the cylinders that it would detonate badly even after setting the timing to old 6 degree specs. If you had a blown it you would know. If however your car had low vacuum for a different reason, it would allow the power valve to open a bit, which would make the pre-existing problem worse. it would run so rich you couldn't fix it with just the idle mixture screws.