I've gone through plenty of gears in my car, with and without a supercharger and can tell you most of the differences in drivability and performance, but if your going all N/A, go with 4.10's, you'll notice the car pulls more as soon as you get on the throttle. I've you have a blower with 4.10's though, I'd suggest you stick with 3.55's if possible, but no more than 3.73's. As far as gas consumption goes, you don't really notice much of a difference in MPG. My car used to cruise at about 2150RPM going 70mph on the freeway with 3.73's, and the difference seems to go up a few hundred RPM's as you upgrade to 4.10 gears and up.