I'm not sure where you guys are getting your info about compression. A friend of mine is running a 496 chevy with 15.5:1 compression and a 300 shot of NOS, no problems. When it gets traction it runs 8.80 all day long. The only problem he has is the oil pump pickup breaking off his motor when it comes down off the willie sometimes (has happened 4 times this year).
Oh and with my 327 and 30# injectors I'm seeing 85% duty cycle.