If you want a car that is efficient on fuel...go get a honda, and be slow! Stangs are not meant to be easy on gas, however compared to a lot of vechicles a mustang gets pretty good gas milage! Before I got my stang I drove a 99dodge ram with a 360 and 44in super swampers!
To answer you question, the TB, Plenum and other bolt on mods ( pullies, cold air) and exhaust mods make your car perform better by increasing the motors efficency by getting colder air in faster and getting it out faster as well. This will only help your gas milage. ;-)